Paola Arlotta: Brain Development from Stem Cell to Organoid | Lex Fridman Podcast #32

Here’s the outline of my conversation with Paola.

0:00 – Introduction
1:05 – How unlikely is the human brain?
5:28 – Brain development process
13:57 – Brain development organization as a distributed vs centralised system
20:08 – Nature vs nurture, hardware vs software
22:38 – Brain organoids
36:40 – Our place in the history of understanding the brain
39:45 – Building a human brain
42:45 – Ethics
49:02 – Lessons from raising kids
52:14 – How has studying the brain changed your understanding of self?
54:08 – Merging with AI

An organoid is a miniaturised and simplified version of an organ produced in vitro in three dimensions that shows realistic micro-anatomy.


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